The Transition Story
From One Cell to Many Different Cells
by Jewel Reuter, LA Virtual School
Donald Cronkite, Hope College



Casey was having breakfast.  His mother had several surgeries to perform that day, so she was hurrying around gathering her papers.  Casey couldn’t help it, he knew she was busy, but he had an important question.

  “Mom, do you have just a few minutes.  I’m trying to understand something you said the other day when we were talking about Parkinson’s disease.”

  “Just a few minutes,” said his mother.  Dad will be driving me to the hospital in just a few minutes.”

  “OK, I’ll hurry.  You said if we wanted to find a cure for Parkinson’s disease, we would have to study embryology and mitosis.  Well, now I’ve studied them, but I don’t have any good ideas about curing Grandpa’s disease.”

  “What do you know about mitosis?”  Mother asked. 

  “Mitosis keeps the chromosome number the same each time the cell divides in two.  I know a song about that….would you like to hear it? “

  “Not right now, but sing it for me tonight at dinner.  But you have a clue there in what you know.  If mitosis keeps all the chromosome numbers the same, what can you say about the genes in every one of our cells?”

  Casey thought a minute and then said, “I guess every cell has the same genes as the original zygote.  They are all alike in their genes but so different otherwise.  Those cells that make the special chemical for coordinating movement are very different from cells that make insulin or some other chemical.”

  “Right you are,” said Mother.  “So if all the cells have the same genes, how could that help Grandpa?”

  “Oh, I see,” said Casey.  All of his cells have the genes for that special chemical.  So if we could  get some of his other cells to make the chemical, he might be cured.  But how could we do that?  When each of the cells have already changed to a specialized cell of some kind, how could you get any of them to become another kind of cell?”

  “Good Question,” said the mother as she put on her coat.  “You should study about embryo cloning and stem cells.  Then we’ll talk again.  See you tonight.”

  “Right,” said Casey.  “See you tonight.”

Attachment #11
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